1.1 HPLC in a modular system which offers unique future proofing and upgrading capabilities. 1.2 Bio-inert Quaternary (4) Pump (600 bar) 1.2.1 Wide flow range up to 10 mL/min that supports standard analytical and semipreparative applications for 4.6 and 3.0 mm id columns. 1.2.2 600 bar maximum pressure to allow smaller particle size columns, longer columns, and/or higher viscous solvents as an alternative to acetonitrile for higher resolution and/or faster separations. 1.2.3 Access to up to four solvents for isocratic or gradient analysis, accelerating method development, preparation of mobile phases, and system flushing. 1.2.4 Easy, fast, and secure transfer of methods from conventional columns to sub2-micron columns. 1.2.5 Integrated high-efficiency degasser with low internal volume based on PTFE AF technology for fast change-over of solvents for purging and priming. 1.2.6 Robust materials to withstand demanding applications. 1.2.7 Seal wash for high-salt mobile phases. 1.3 Bio-inert Multisampler 1.3.1 Capacity of up to 2 well plates (96- or 384-well format). 1.3.2 Injections from 0.1 to 100 µL at up to 600 bar. 1.3.3 Injection volume extension up to 1,800 µL for microbore to semipreparative applications. 1.3.4 Needle flush port enables rinsing the outside surfaces of the needle for lowest carryover 1.3.5 Integrated column compartment to hold two columns up to 30 cm length, and to provide heating from 5 degrees above ambient to 80 °C for reproducible chromatographic data at optimized resolution. 1.3.6 Low internal volume. 1.3.7 Overlapped sample runs and injection cycles. 1.3.8 Customizable injection program for advanced injection sequences or sample preparation prior to injection.